science.nexvigilant.com

3 configs22 tools19 verified

/targets/**/genomics/**/hexim1/**

[NexVigilant Science Station] Drug Target Intelligence

AI-powered drug target analysis — ChEMBL bioactivity, UniProt profiles, PDB structures, clinical candidate pipelines, and target safety assessment. Built by NexVigilant (https://nexvigilant.com). DISCLAIMER: This WebMCP configuration was developed by NexVigilant, LLC and is provided as a community resource to assist AI agents in navigating pharmacovigilance and drug research tools. NexVigilant is not responsible for, and does not officially endorse third-party use of this configuration, and expressly disclaims any and all liability for damages of any kind arising out of the use, reference to, or reliance upon any information or actions performed through this resource. No guarantee is provided that the content is correct, accurate, complete, up-to-date, or that the underlying site structure has not changed. This tool is for educational and professional development purposes only and does not constitute medical or regulatory advice. Built by NexVigilant (https://nexvigilant.com) — Empowerment Through Vigilance.

search-targets/targets/**extractverified

by MatthewCampCorp

[NexVigilant Science Station] Search ChEMBL for drug targets by gene name, protein name, or disease

Input Schema

{
  "type": "object",
  "properties": {}
}

Annotations

{
  "readOnlyHint": "true",
  "idempotentHint": "true",
  "destructiveHint": "false"
}

Execution Metadata

Selector: body

Auto-submit: false

Result selector: body

Result extract: text

get-target-profile/targets/**extractverified

by MatthewCampCorp

[NexVigilant Science Station] Get comprehensive target profile from UniProt — protein function, structure, subcellular location, and disease associations

Input Schema

{
  "type": "object",
  "properties": {}
}

Annotations

{
  "readOnlyHint": "true",
  "idempotentHint": "true",
  "destructiveHint": "false"
}

Execution Metadata

Selector: body

Auto-submit: false

Result selector: body

Result extract: text

get-crystal-structures/targets/**extractverified

by MatthewCampCorp

[NexVigilant Science Station] Search PDB/RCSB for crystal structures of a target — resolution, method, and ligand co-crystals

Input Schema

{
  "type": "object",
  "properties": {}
}

Annotations

{
  "readOnlyHint": "true",
  "idempotentHint": "true",
  "destructiveHint": "false"
}

Execution Metadata

Selector: body

Auto-submit: false

Result selector: body

Result extract: text

search-clinical-candidates/targets/**extract

by MatthewCampCorp

[NexVigilant Science Station] Get clinical candidate compounds targeting a specific protein from ChEMBL bioactivity data

Input Schema

{
  "type": "object",
  "properties": {}
}

Annotations

{
  "readOnlyHint": "true",
  "idempotentHint": "true",
  "destructiveHint": "false"
}

Execution Metadata

Selector: body

Auto-submit: false

Result selector: body

Result extract: text

get-target-safety/targets/**extractverified

by MatthewCampCorp

[NexVigilant Science Station] Get published safety liabilities of modulating a target — knockout phenotypes, toxicity reports, and risk factors

Input Schema

{
  "type": "object",
  "properties": {}
}

Annotations

{
  "readOnlyHint": "true",
  "idempotentHint": "true",
  "destructiveHint": "false"
}

Execution Metadata

Selector: body

Auto-submit: false

Result selector: body

Result extract: text

compute-target-score/targets/**extractverified

by MatthewCampCorp

[NexVigilant Science Station] Assess drug target druggability using multi-factor scoring — protein family, structural data, clinical precedent, genetic validation

Input Schema

{
  "type": "object",
  "properties": {}
}

Annotations

{
  "readOnlyHint": "true",
  "idempotentHint": "true",
  "destructiveHint": "false"
}

Execution Metadata

Selector: body

Auto-submit: false

Result selector: body

Result extract: text

[NexVigilant Science Station] Genomics & Expression Mining

/genomics/**View config →

Gene expression mining via NCBI GEO, variant searching, pathway enrichment, and protein interaction networks. Public API-powered genomics intelligence. Built by NexVigilant (https://nexvigilant.com). DISCLAIMER: This WebMCP configuration was developed by NexVigilant, LLC and is provided as a community resource to assist AI agents in navigating pharmacovigilance and drug research tools. NexVigilant is not responsible for, and does not officially endorse third-party use of this configuration, and expressly disclaims any and all liability for damages of any kind arising out of the use, reference to, or reliance upon any information or actions performed through this resource. No guarantee is provided that the content is correct, accurate, complete, up-to-date, or that the underlying site structure has not changed. This tool is for educational and professional development purposes only and does not constitute medical or regulatory advice. Built by NexVigilant (https://nexvigilant.com) — Empowerment Through Vigilance.

search-geo-datasets/genomics/**extractverified

by MatthewCampCorp

[NexVigilant Science Station] Search NCBI GEO for gene expression datasets by gene, treatment, disease, or tissue

Input Schema

{
  "type": "object",
  "properties": {}
}

Annotations

{
  "readOnlyHint": "true",
  "idempotentHint": "true",
  "destructiveHint": "false"
}

Execution Metadata

Selector: body

Auto-submit: false

Result selector: body

Result extract: text

get-expression-profile/genomics/**extractverified

by MatthewCampCorp

[NexVigilant Science Station] Get tissue expression profile for a gene by mining GEO profiling datasets

Input Schema

{
  "type": "object",
  "properties": {}
}

Annotations

{
  "readOnlyHint": "true",
  "idempotentHint": "true",
  "destructiveHint": "false"
}

Execution Metadata

Selector: body

Auto-submit: false

Result selector: body

Result extract: text

search-variants/genomics/**extract

by MatthewCampCorp

[NexVigilant Science Station] Search literature for clinically relevant gene variants — pathogenic mutations, pharmacogenomic variants

Input Schema

{
  "type": "object",
  "properties": {}
}

Annotations

{
  "readOnlyHint": "true",
  "idempotentHint": "true",
  "destructiveHint": "false"
}

Execution Metadata

Selector: body

Auto-submit: false

Result selector: body

Result extract: text

get-pathway-enrichment/genomics/**extractverified

by MatthewCampCorp

[NexVigilant Science Station] Find KEGG/Reactome pathway associations for a gene or gene list via literature mining

Input Schema

{
  "type": "object",
  "properties": {}
}

Annotations

{
  "readOnlyHint": "true",
  "idempotentHint": "true",
  "destructiveHint": "false"
}

Execution Metadata

Selector: body

Auto-submit: false

Result selector: body

Result extract: text

search-protein-interactions/genomics/**extractverified

by MatthewCampCorp

[NexVigilant Science Station] Find protein-protein interaction partners from STRING/BioGRID literature

Input Schema

{
  "type": "object",
  "properties": {}
}

Annotations

{
  "readOnlyHint": "true",
  "idempotentHint": "true",
  "destructiveHint": "false"
}

Execution Metadata

Selector: body

Auto-submit: false

Result selector: body

Result extract: text

search-literature/genomics/**extractverified

by MatthewCampCorp

[NexVigilant Science Station] General PubMed literature search across biomedical topics

Input Schema

{
  "type": "object",
  "properties": {}
}

Annotations

{
  "readOnlyHint": "true",
  "idempotentHint": "true",
  "destructiveHint": "false"
}

Execution Metadata

Selector: body

Auto-submit: false

Result selector: body

Result extract: text

[NexVigilant Science Station] HEXIM1 Research Notebooks — PTEFb Pathway & Drug Target Intelligence

/hexim1/**View config →

Interactive Voila-served research notebooks exploring HEXIM1 as a drug target: PTEFb pathway mechanics, BET/HDAC inhibitor analysis, biomarker validation, GEO expression mining, experimental protocols, and IP strategy. 12 notebooks covering the full translational pipeline from molecular biology to patent landscape. DISCLAIMER: This WebMCP configuration was developed by NexVigilant, LLC and is provided as a community resource to assist AI agents in navigating pharmacovigilance and drug research tools. NexVigilant is not responsible for, and does not officially endorse third-party use of this configuration. Built by NexVigilant (https://nexvigilant.com) — Empowerment Through Vigilance. DISCLAIMER: This WebMCP configuration was developed by NexVigilant, LLC and is provided as a community resource to assist AI agents in navigating pharmacovigilance and drug research tools. NexVigilant is not responsible for, and does not officially endorse third-party use of this configuration, and expressly disclaims any and all liability for damages of any kind arising out of the use, reference to, or reliance upon any information or actions performed through this resource. No guarantee is provided that the content is correct, accurate, complete, up-to-date, or that the underlying site structure has not changed. This tool is for educational and professional development purposes only and does not constitute medical or regulatory advice. Built by NexVigilant (https://nexvigilant.com) — Empowerment Through Vigilance.

get-ptefb-pathway/hexim1/**extractverified

by MatthewCampCorp

[NexVigilant Science Station] Get interactive PTEFb pathway diagram showing HEXIM1 inhibition of P-TEFb kinase complex, CDK9/CyclinT1 interaction, and transcriptional elongation checkpoint

Input Schema

{
  "type": "object",
  "properties": {}
}

Annotations

{
  "readOnlyHint": "true",
  "idempotentHint": "true",
  "destructiveHint": "false"
}

Execution Metadata

Selector: body

Auto-submit: false

Result selector: body

Result extract: text

search-bet-inhibitors/hexim1/**extractverified

by MatthewCampCorp

[NexVigilant Science Station] Search BET bromodomain inhibitor data including JQ1, I-BET151, OTX015 — mechanism of action, selectivity profiles, and HEXIM1 upregulation evidence

Input Schema

{
  "type": "object",
  "properties": {}
}

Annotations

{
  "readOnlyHint": "true",
  "idempotentHint": "true",
  "destructiveHint": "false"
}

Execution Metadata

Selector: body

Auto-submit: false

Result selector: body

Result extract: text

search-hdac-inhibitors/hexim1/**extractverified

by MatthewCampCorp

[NexVigilant Science Station] Search HDAC inhibitor data including vorinostat, panobinostat, romidepsin — epigenetic mechanisms and HEXIM1 expression modulation

Input Schema

{
  "type": "object",
  "properties": {}
}

Annotations

{
  "readOnlyHint": "true",
  "idempotentHint": "true",
  "destructiveHint": "false"
}

Execution Metadata

Selector: body

Auto-submit: false

Result selector: body

Result extract: text

get-biomarker-validation/hexim1/**extractverified

by MatthewCampCorp

[NexVigilant Science Station] Get HEXIM1 biomarker validation data — expression levels across tissues, disease associations, and validation status for use as a pharmacodynamic biomarker

Input Schema

{
  "type": "object",
  "properties": {}
}

Annotations

{
  "readOnlyHint": "true",
  "idempotentHint": "true",
  "destructiveHint": "false"
}

Execution Metadata

Selector: body

Auto-submit: false

Result selector: body

Result extract: text

mine-geo-expression/hexim1/**extract

by MatthewCampCorp

[NexVigilant Science Station] Mine NCBI GEO for HEXIM1 gene expression datasets — differential expression under drug treatment, tissue-specific profiles, and fold-change data

Input Schema

{
  "type": "object",
  "properties": {}
}

Annotations

{
  "readOnlyHint": "true",
  "idempotentHint": "true",
  "destructiveHint": "false"
}

Execution Metadata

Selector: body

Auto-submit: false

Result selector: body

Result extract: text

get-hypothesis-tracker/hexim1/**extractverified

by MatthewCampCorp

[NexVigilant Science Station] Get current hypothesis status board — active research hypotheses, evidence for/against, confidence levels, and next experimental steps

Input Schema

{
  "type": "object",
  "properties": {}
}

Annotations

{
  "readOnlyHint": "true",
  "idempotentHint": "true",
  "destructiveHint": "false"
}

Execution Metadata

Selector: body

Auto-submit: false

Result selector: body

Result extract: text

get-ifn-pathway/hexim1/**extractverified

by MatthewCampCorp

[NexVigilant Science Station] Get interferon pathway analysis — HEXIM1 role in IFN signaling, antiviral response, and immune modulation via P-TEFb regulation

Input Schema

{
  "type": "object",
  "properties": {}
}

Annotations

{
  "readOnlyHint": "true",
  "idempotentHint": "true",
  "destructiveHint": "false"
}

Execution Metadata

Selector: body

Auto-submit: false

Result selector: body

Result extract: text

get-experimental-protocols/hexim1/**extractverified

by MatthewCampCorp

[NexVigilant Science Station] Get validated experimental protocols for HEXIM1 research — ChIP-seq, RT-qPCR, Western blot conditions, cell line recommendations

Input Schema

{
  "type": "object",
  "properties": {}
}

Annotations

{
  "readOnlyHint": "true",
  "idempotentHint": "true",
  "destructiveHint": "false"
}

Execution Metadata

Selector: body

Auto-submit: false

Result selector: body

Result extract: text

get-patent-landscape/hexim1/**extractverified

by MatthewCampCorp

[NexVigilant Science Station] Get HEXIM1-related patent landscape — existing IP, white space analysis, freedom-to-operate assessment, and strategic filing opportunities

Input Schema

{
  "type": "object",
  "properties": {}
}

Annotations

{
  "readOnlyHint": "true",
  "idempotentHint": "true",
  "destructiveHint": "false"
}

Execution Metadata

Selector: body

Auto-submit: false

Result selector: body

Result extract: text

get-replication-failures/hexim1/**extractverified

by MatthewCampCorp

[NexVigilant Science Station] Get documented replication failures and negative results from HEXIM1 research — what didn't work and why, to prevent redundant experiments

Input Schema

{
  "type": "object",
  "properties": {}
}

Annotations

{
  "readOnlyHint": "true",
  "idempotentHint": "true",
  "destructiveHint": "false"
}

Execution Metadata

Selector: body

Auto-submit: false

Result selector: body

Result extract: text